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| Antigenic Specificity | Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | mouse, rat, human |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 200 µg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB),Immunohistochemistry (IHC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Caspase-10 is a DED (death effector domain)-containing caspase and functions as an initiator caspase in Fas/TNF induced apoptosis. Four isoforms of caspase-10 have been identified: caspase-10a (Mch4), caspase-10b (FLICE2), caspase-10c and caspase-10d. They have the same prodomain but different mature large and small subdomains. Upon death ligand-receptor binding, caspase-10 is coupled to the multimeric Fas/TNF receptor complex via DED/FADD adaptor interaction. This complex processes procaspase-10 into a large active fragment and a small fragment. Cleaved caspase-10 further processes other caspase members, including caspase-3 and caspase-7, to initiate a caspase cascade, leading to apoptosis.Synonyms: CASP10 , MCH4, Caspase 10, FLICE2, CASP 10, ICE like apoptotic protease 4 |
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| Immunogen | Recombinant protein of human CASP10 |
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| Other Names | xCaspase-10|alps2|caspace-10|caspase-10|flice2|mch4|xCaspace-10|ALPS2|FLICE2|MCH4 |
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| Gene, Accession # | Gene ID: 843 |
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| Catalog # | ABIN1513858 |
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| Price | |
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| Order / More Info | Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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