| 产品详情 |
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| Product Name | Recombinant Human Poly [ADP-ribose] polymerase 1 (PARP11), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 41kDa. Partial: 2-331aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Involved in the base excision repair (BER) pathway, by catalyzing the poly (ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly (ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | ADP-ribosyltransferase diphtheria toxin-like 1; ARTD1NAD (+) ADP-ribosyltransferase 1; ADPRT 1; Poly[ADP-ribose] synthase 1 |
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| Gene, Accession, CAS # | PARP11, UniProt: Q9NR21 |
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| Catalog # | RPC21788 |
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| Order / More Info | Recombinant Human Poly [ADP-ribose] polymerase 1 (PARP11), partial from BIOMATIK |
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| Product Specific References | n/a |
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