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| Product Name | Recombinant Human Podocalyxin protein (PODXL), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 46.2kDa. Partial: 32-458aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma mbrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | GCTM-2 antigen; Gp200Podocalyxin-like protein 1; PC; PCLP-1 |
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| Gene, Accession, CAS # | PODXL, UniProt: O00592 |
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| Catalog # | RPC25321 |
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| Order / More Info | Recombinant Human Podocalyxin protein (PODXL), partial from BIOMATIK |
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| Product Specific References | n/a |
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