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| Product Name | Proteasome (Prosome, Macropain) Subunit, alpha Type, 7 (PSMA7) (AA 1-248) protein (His tag) |
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| Description | The proteasome is a multicatalytic proteinase complex with a highly assembled ring-shaped 20S core structure which is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are found throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. PSMA7 is part of the peptidase T1A family, that is a 20S core alpha subunit. PSMA7 interacts particularly with the hepatitis B virus X protein, a protein critical to viral replication. PSMA7 is involved in regulating hepatitis virus C internal ribosome entry site activity that is crucial for viral replication. PSMA7 is in charge for regulating the hypoxia-inducible factor-1alpha, a transcription factor important for cellular responses to oxygen tension. PSMA7 is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. PSMA7 interacts specifically with two subdomains of HIF-1alpha and inhibited the transactivation function of HIF-1alpha under both normoxic and hypoxia-mimicking conditions Synonyms: HSPC, RC6-1, XAPC7, MGC3755, PSMA-7, Proteasome subunit alpha type-7, Proteasome subunit RC6-1, Proteasome subunit XAPC7, PSMA7, C6 |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | DDBDRAFT_0185059|DDBDRAFT_0217080|DDB_0185059|DDB_0217080|hspc|rc6-1|xapc7|XAPC7|psma7|zgc:77139|C6-I|C6|HSPC|RC6-1 |
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| Gene, Accession, CAS # | Gene ID: 5688 |
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| Catalog # | ABIN805668 |
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| Order / More Info | Proteasome (Prosome, Macropain) Subunit, alpha Type, 7 (PSMA7) (AA 1-248) protein (His tag) from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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