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| Product Name | SLAM Family Member 6 (SLAMF6) (C-Term), (AA 22-226) protein (His tag) |
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| Description | Recombinant Human SLAM Family Member 6/SLAMF6 is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (Gln22-Met226) of Human SLAMF6 fused with a polyhistidine tag at the C-terminus. SLAM Family Member 6 (SLAMF6) is a 60 kDa single-pass type I membrane protein that belongs to the SLAM subgroup of the CD2 family. Human SLAMF6/ NTB-A contains a 205 AA extracellular domain (ECD) with one Ig-like V-set and one Ig-like C2-set domain, a 21 AA transmembrane segment and an 84 AA cytoplasmic domain, with two immunoreceptor tyrosine-based switch motifs. SLAMF6 is a homodimer. SLAMF6 can interact with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. Phosphorylation-dependent NTB-A association with SAP is required for full production of IFN-γ by NK cells and independent of EAT-2 binding. It Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. On B cells, NTB-A modulates immunoglobulin class switching and the balance between tolerance and autoimmunity. |
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| Size | 10 µg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | SLAMF6|CD352|KALI|KALIb|Ly108|NTB-A|NTBA|SF2000|KAL1|KAL1b|RGD1561848 |
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| Gene, Accession, CAS # | Gene ID: 114836 |
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| Catalog # | ABIN1097247 |
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| Order / More Info | SLAM Family Member 6 (SLAMF6) (C-Term), (AA 22-226) protein (His tag) from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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