| 产品详情 |
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| Product Name | SLAM Family Member 7 (SLAMF7) (AA 23-225) protein (His tag) |
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| Description | SLAMF7 is a single-pass type I membrane protein and contains 1 Ig-like C2-type (immunoglobulin-like) domain. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruite signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP. SLAMF7 positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, SLAMF7 can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.Alternative Names: SLAM Family Member 7, CD2 Subset 1, CD2-Like Receptor-Activating Cytotoxic Cells, CRACC, Membrane Protein FOAP-12, Novel Ly9, Protein 19A, CD319, SLAMF7, CS1 |
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| Size | 500 µg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | RGD1560190|SLAMF7|slaf7|19A|CD319|CRACC|CS1|19A24|4930560D03Rik |
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| Gene, Accession, CAS # | Gene ID: 57823 |
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| Catalog # | ABIN1691055 |
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| Order / More Info | SLAM Family Member 7 (SLAMF7) (AA 23-225) protein (His tag) from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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