| 产品详情 |
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| Product Name | Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) (ITCH) (Isoform 2) protein |
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| Description | The mammalian Itchy homolog, or ITCH, (also known as Atrophin-1-interacting protein 4 or AIP4) is a HECT domain class ubiquitin E3 ligase. ITCH/AIP4 ubiquitinates the phosphorylated form of dishevelled protein and promotes its degradation via the ubiquitin proteasome system, thereby inhibiting canonical Wnt signaling. The absence of ITCH/AIP4 has been shown to cause severe autoimmune disease in mice. Recent studies have identified multisystem autoimmune disease and morphologic and developmental abnormalities in human patients with ITCH/AIP4 deficiency, thus underscoring the importance of ITCH/AIP4 in many cellular processes. This ligase may catalyze K29-, K48-, and/or K63-linked polyubiquitin chain formation on a variety of reported targets. |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | SDS-PAGE (SDS) |
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| Other Names | AIF4|AIP4|NAPP1|dJ468O1.1|6720481N21Rik|8030492O04Rik|A130065M08|C230047C07Rik |
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| Gene, Accession, CAS # | Gene ID: 83737 |
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| Catalog # | ABIN2745731 |
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| Order / More Info | Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) (ITCH) (Isoform 2) protein from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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