| 产品详情 |
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| Antigenic Specificity | STUB1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 80 µl, 400 µl |
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| Concentration | n/a |
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| Applications | WB, IHC. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CHIP is an E3 ligase for nNOS whose action is facilitated by (and possibly requires) its interaction with nNOS-bound hsp70. Co-chaperone CHIP, possibly with another E3 ligase (s), modulates the ubiquitylation of mutant Cu/Zn-superoxide dismutase and renders them more susceptible for proteasomal degradation. CHIP functions as a negative regulator of AR transcriptional activity by promoting AR degradation. CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival. CHIP can interact with the Smad1/Smad4 proteins and block BMP signal transduction through the ubiquitin-mediated degradation of Smad proteins. CHIP E3 controls both the association of Hsp70/Hsp90 chaperones with ErbB2 and the down-regulation of ErbB2 induced by inhibitors of Hsp90. CHIP is associated with Parkin and enhances its ubiquitin ligase activity related to Parkinson's disease. This STUB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 203-231 amino acids from the C-terminal region of human STUB1. |
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| Immunogen | Human STUB1. |
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| Other Names | E3 ubiquitin-protein ligase CHIP; Antigen NY-CO-7; STUB1; CHIP; CLL-associated antigen KW-8; Carboxy terminus of Hsp70-interacting protein; STIP1 homology and U box-containing protein 1; HSPABP2; NY-CO-7; SDCCAG7; UBOX1 |
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| Gene, Accession # | Accession: NP_005852.2, SwissProt: Q9UNE7 |
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| Catalog # | abx025112 |
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| Price | |
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| Order / More Info | STUB1 Antibody from ABBEXA |
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| Product Specific References | n/a |
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