| 产品详情 |
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| Antigenic Specificity | CD63 Molecule (CD63) |
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| Clone | R5G2 |
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| Host Species | Rat |
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| Reactive Species | mouse |
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| Isotype | IgG2b |
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| Format | Protein G purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FACS),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CD63 is not only expressed on activated platelets, but also activated monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and translocated to cell surface upon various stimuli. The membrane of lytic granules in CTLs contains CD63/LAMP-3 and other lysosomal-associated glycoproteins (LAMPs) such as CD107a/LAMP-1 and CD107b/LAMP-2. LAMPs have b een observed on the cell surface as a result of degranulation. CD63 belongs to a member of the tetraspanin transmembrane-protein (TM4) superfamily, which includes CD9, CD37, CD53, CD81, CD82, CD151 and CD231. Several members of this family form noncovalent associations with integrins, particularly β 1 integrins (CD29), and modulate cellular adhesion properties. CD63 has a tyrosine-based internalization motif in the cytoplasmic C-terminal tail and interacts with adaptor protein complexes such as AP-2 and AP-3. Because AP-2 and AP-3 are involved in facilitating the clathrin-mediated endocytosis, CD63 could be directly involved in the internalization of its membrane protein partners.Synonyms: Granulophysin, ME491, MLA1, Melanoma-associated antigen ME491, OMA81H, Ocular melanoma-associated antigen, TSPAN30, Tetraspanin-30 |
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| Immunogen | n/a |
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| Other Names | C75951|ME491|Tspan30|LAMP-3|MLA1|OMA81H|TSPAN30|TSP29FA |
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| Gene, Accession # | Gene ID: 12512 |
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| Catalog # | ABIN2853613 |
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| Price | |
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| Order / More Info | CD63 Molecule (CD63) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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