| 产品详情 |
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| Product Name | Serine (Or Cysteine) Peptidase Inhibitor, Clade G, Member 1 (SERPING1) (AA 23-500) protein (His tag) |
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| Description | The Human Serpin superfamily consists of at least 35 members that target not only serine proteases, but also selected cysteine proteases and non-protease proteins. As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. They are also involved in activities that extend beyond their ability to inhibit proteases. For instance, they may also regulate blood pressure, angiogenesis. Serpin G1 is a serine protease inhibitor protein. Serpin G1 is the largest member among the serpin class of proteins. Remarkably, Serpin G1 has a 2-domain structure, unlike most family members. The C-terminal serpin domain is similar to other serpins, and this part of Serpin G1 provides the inhibitory activity. The N-terminal domain is not essential for Serpin G1 to inhibit proteinases and has no similarity to other proteins. The main function of Serpin G1 is the inhibition of the complement system to prevent spontaneous activation. Serpin G1 is an acute phase protein and circulates in blood at levels of around 0.25g/L, whose levels rise 2-fold during inflammation. Although named after its complement inhibitory activity, Serpin G1 also inhibits proteinases of the fibrinolytic, clotting, and kinin pathways. Most notably, Serpin G1 play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. It is also the most important physiological inhibitor of fXIIa, chymotrypsin and plasma kallikrein.Alternative Names: Plasma Protease C1 Inhibitor, C1 Inh, C1Inh, C1 Esterase Inhibitor, C1-Inhibiting Factor, Serpin G1, SERPING1, C1IN, C1NH |
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| Size | 10 µg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Gene ID: 710 |
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| Catalog # | ABIN1097528 |
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| Order / More Info | Serine (Or Cysteine) Peptidase Inhibitor, Clade G, Member 1 (SERPING1) (AA 23-500) protein (His tag) from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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