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| Product Name | Recombinant Cricetulus griseus Protein disulfide-isomerase (P4HB) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 57kDa. Full Length of Mature Protein: 20-509aa. N-terminal 6xHis-tagged. Chinese hamster. This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Prolyl 4-hydroxylase subunit beta; p58 |
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| Gene, Accession, CAS # | P4HB, UniProt: Q8R4U2 |
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| Catalog # | RPC25466 |
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| Order / More Info | Recombinant Cricetulus griseus Protein disulfide-isomerase (P4HB) from BIOMATIK |
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| Product Specific References | n/a |
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