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| Antigenic Specificity | Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) |
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| Clone | polyclonal |
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| Host Species | Goat |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | biotin conjugate |
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| Size | 50 µg |
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| Concentration | n/a |
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| Applications | Enzyme Immunoassay (EIA),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | RANKL is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. There are three isoforms of RANKL. Human RANKL is a soluble 20 kDa polypeptide, comprising the TNF homologous region of RANKL (176 amino acid residues). This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor associated factor (TRAF) 6, which indicated that this protein may have a role in the regulation of cell apoptosis. RANKL deficient mice show severe osteoporesis and complete absence of osteoclasts as a result of lack of osteogenesis.Synonyms: ODF, OPGL, Osteoclast differentiation factor, Osteoprotegerin ligand, RANK Ligand, RANKL, Receptor activator of nuclear factor kappa B ligand, TNF-related activation-induced cytokine, TNFSF11, TRANCE, Tumor necrosis factor ligand superfamily member 11 |
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| Immunogen | Highly pure (> 98 %) recombinant human sRANKL |
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| Other Names | TNFSF11|BTF3L1|HUMBTFB|OCIF|OPG|TNFRSF11B|CD254|ODF|OPGL|OPTB2|RANKL|TRANCE|hRANKL2|sOdf|Ly109l|Trance|Opg |
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| Gene, Accession # | Gene ID: 8600 |
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| Catalog # | ABIN181553 |
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| Order / More Info | Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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