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| Product Name | RSPO-1, Recombinant, Human (R-Spondin 1, Roof Plate-specific Spondin1) |
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| Description | Purity ≥ 90% (SDS-PAGE). R-Spondin 1 (RSPO1, roof plate-specific spondin1), also called cysteine-rich and single thrombospondin domain containing-3 (Cristin 3), is a 27kD secreted protein that shares ~40% amino acid identity with the other three R-Spondin family members (1, 2). All are positive modulators of Wnt/b-catenin signaling, but each has a distinct expression pattern (1-3). Like other R-spondins, R-Spondin1 contains two adjacent cysteine-rich furin-like domais (aa34-135) with one potential N-glycosylation site (aa36), followed by a thrombospondin (TSP-1) motif (aa147-207) and a region rich in basic residues (aa211-263). Only the furin-like domains are needed for b-catenin stabilization (2,4). A putative nuclear localization signal at the C-terminus may allow some expression in the nucleus (5). Potential isoforms of 200 and 236aa have an alternate, shorter N-terminus or are missing aa146-208, respectively (6). Over aa21-263, human R-Spondin 1 shares 89%, 87%, 92%, 91%, 91% and 8 |
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| Size | 25ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: Q2MKA7 |
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| Catalog # | R9417-45A |
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| Order / More Info | RSPO-1, Recombinant, Human (R-Spondin 1, Roof Plate-specific Spondin1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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