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| Product Name | RSPO3, Recombinant, Human (R-Spondin-3, PWTSR, THSD2, Roof Plate-Specific Spondin-3) |
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| Description | Purity ~95% (SDS-PAGE). The R-Spondin (Rspo) proteins belong to the Rspo family of Wnt modulators. Currently, the family consists of four structurally related secreted ligands (Rspo 1-4), all containing furin-like and thrombospondin structural domains. The Rspo proteins can interact with the Frizzled/LRP6 receptor complex in a manner that causes the stabilization and resulting accumulation of the intracellular signaling protein, beta-catenin. This activity effectively activates and increases the subsequent nuclear signaling of beta-catenin. R-Spondin can also bind to the previously discovered G-protein coupled receptors, LGR-4 and LGR-5. Rspo/beta-catenin signaling can act as an inducer of the transformed phenotype, and can also regulate the proliferation and differentiation of certain stem cell populations. Recombinant human R-Spondin-3 is a 26.9kD protein consisting of 240aa residues. Due to glycosylation, R-Spondin-3 migrates at an apparent molecular weight of ~37kD by SDS PAGE anal |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | RSPO3, Gene ID: 84870, SwissProt: Q9BXY4 |
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| Catalog # | 220238 |
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| Order / More Info | RSPO3, Recombinant, Human (R-Spondin-3, PWTSR, THSD2, Roof Plate-Specific Spondin-3) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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