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| Product Name | RSPO-2, Recombinant, Human |
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| Description | Purity ~ 90%, as determined by SDS-PAGE under reducing conditions and visualized by silver stain. Endotoxin: ≤ 1EU. Human Roof plate-specific Spondin 2 isoform 1 (R-Spondin 2, RSPO-2), also known as cysteine-rich and single thrombospondin domain containing protein 2 (Cristin 2), is a 33kD secreted protein that belongs to the R-Spondin family. The four known human R-Spondins regulate -catenin signaling and overlap in expression and function (1-3). Like other R-Spondins, R-Spondin 2 contains two adjacent cysteine-rich furin-like domains (aa 90-134) followed by a thrombospondin (TSP-1) motif (aa 144-204) and a C-terminal region rich in basic residues (aa 207-243). The basic region appears to mediate cell surface retention but not to influence function (1). R-Spondin 2 contains one potential N-glycosylation site. Of the three reported splice isoforms of human R-Spondin 2, isoform 2 lacks residues 1-67 of isoform 1, while isoform 3 has a glycine substitution for residues 32-95 of isoform 1. |
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| Size | 25ug |
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| Concentration | n/a |
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| Applications | ELISA WB |
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| Other Names | RSPO-2, Recombinant, Human (R-Spondin 2, Cysteine-rich and Single Thrombospondin Domain Containing Protein 2, Cristin 2) |
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| Gene, Accession, CAS # | Accession: NP_848660 |
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| Catalog # | R9417-47 |
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| Order / More Info | RSPO-2, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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