| 产品详情 |
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| Product Name | Ubiquitin-Conjugating Enzyme E2A (ube2a) protein (His tag) |
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| Description | Homolog of Rad6 A (HR6A), also known as ubiquitin-conjugating Enzyme E2A (UBE2A), is a ubiquitously expressed member of the ubiquitin-conjugating (E2) enzyme family that is highly expressed in the brain and heart. HR6A/UBE2A has a predicted molecular weight of 17 kDa. The human protein shares 100% amino acid sequence identity with the mouse and rat orthologs. Like other E2 family members, HR6A/UBE2A has an E2 catalytic core domain that contains an active site cysteine residue required for the formation of a thioester bond with ubiquitin. HR6A/UBE2A is involved in many cellular processes including protein degradation, transcriptional regulation and the DNA damage response. HR6A/UBE2A functions with the UBR2 ubiquitin ligase (E3) to mediate ubiquitination of target substrates degraded through the N-end rule proteolytic pathway. HR6A/UBE2A also interacts with the human BRE1 E3 to ubiquitinate Histone H2B on Lys120, which promotes transcription via methylation of Histone H3 on Lys4. HR6A/UBE2A is activated via phosphorylation on Ser120 by CDK9 following exposure to UVC irradiation and HR6A/UBE2A-RAD18-dependent ubiquitination of PCNA is required for DNA damage tolerance. HR6A/UBE2A also regulates the mRNA and protein levels of p53. |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | SDS-PAGE (SDS) |
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| Other Names | BHR6A|HR6A|hhr6a|rad6a|ubc2|mp:zf637-2-000771|si:bz46j2.4|wu:fa01h11|HHR6A|MRXS30|MRXSN|RAD6A|UBC2|Mhr6a |
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| Gene, Accession, CAS # | Gene ID: 7319 |
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| Catalog # | ABIN2745703 |
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| Price | |
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| Order / More Info | Ubiquitin-Conjugating Enzyme E2A (ube2a) protein (His tag) from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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