| 产品详情 |
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| Product Name | Human CellExp™ Fc gamma RIV / CD16-2, Mouse recombinant |
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| Description | Purity >90%. This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 22.8 kDa. The protein migrates as 28-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. FcgR4 (Low affinity immunoglobulin gamma Fc region receptor IV) is also known as CD16-2, FcgammaRIV, receptor for the Fc region of immunoglobulin gamma. Also acts as a receptor for the Fc region of immunoglobulin epsilon. Binds with intermediate affinity to both IgG2a and IgG2b. Does not display binding to IgG1 or IgG3. Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a. Binds with low affinity to both the a and b allotypes of IgE. Has also been shown to bind to IgE allotype a only but not to allotype b. Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of proinflammatory cytokines and the late phase of cutaneous allergic reactions. |
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| Size | 10 µg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Fc gamma RIV, CD16-2, Fcgr4 |
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| Gene, Accession, CAS # | Fcgr4, Gene ID: 246256, Accession: A0A0B4J1G0 |
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| Catalog # | P1426-10 |
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| Order / More Info | Human CellExp™ Fc gamma RIV / CD16-2, Mouse recombinant from BIOVISION, INC. |
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| Product Specific References | n/a |
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