| 产品详情 |
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| Antigenic Specificity | FLT4 / VEGFR3 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | biotin conjugate |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | ELISA |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | FLT4 / VEGFR3 Antibody (Biotin) LS-C500166. Specificity: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'. |
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| Immunogen | Recombinant Human Vascular endothelial growth factor receptor 3 protein (1112-1329AA) |
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| Other Names | FLT4, FLT41, Fms-related tyrosine kinase 4, Fms-like tyrosine kinase 4, LMPH1A, PCL, Soluble VEGFR3 variant 1, Vegf-r3, VEGFR3, Soluble VEGFR3 variant 2, Soluble VEGFR3 variant 3, FLT-4, Quek2, VEGF Receptor 3, VEGFR-3 |
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| Gene, Accession # | FLT4, Gene ID: 2324 |
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| Catalog # | LS-C500166 |
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| Price | |
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| Order / More Info | FLT4 / VEGFR3 Antibody from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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