| 产品详情 |
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| Product Name | SR 9186 |
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| Description | A selective inhibitor of CYP3A4 (IC50 = 0.011 µM); highly selective for CYP3A4 over CYP3A5 (IC50 = 33 µM); inhibits metabolism of midazolam to 1'-hydroxy midazolam, testosterone to 6β-hydroxy testosterone, and vincristine to vincristine M1 in HLMs expressing CYP3A4 (IC50s = 9, 4, and 38 nM, respectively) but not those expressing CYP3A5; decreases lapatinib-induced quinoneimine-glutathione adduct formation in HLMs by 78% at 2.5 µM |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | SR9186 CYP450 CYP-450 3A4 3A5 M-1 |
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| Gene, Accession, CAS # | CAS: 1361414-26-7 |
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| Catalog # | 13888-1 |
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| Price | |
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| Order / More Info | SR 9186 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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