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| Product Name | Recombinant Human Muscle, skeletal receptor tyrosine-protein kinase (MUSK), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 78.8kDa. partial of Isoform 2: 24-495aa. N-terminal GST-tagged. Homo sapiens (Human). Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic mbrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to mbranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous syst by mediating cholinergic responses, synaptic plasticity and mory formation.1 Publication |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Muscle-specific tyrosine-protein kinase receptor; MuSK; Muscle-specific kinase receptor |
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| Gene, Accession, CAS # | MUSK, UniProt: O15146 |
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| Catalog # | RPC21703 |
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| Order / More Info | Recombinant Human Muscle, skeletal receptor tyrosine-protein kinase (MUSK), partial from BIOMATIK |
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| Product Specific References | n/a |
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