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| Product Name | Recombinant Human Muscleblind-like protein 1 |
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| Description | 1-382aa; Full Length of Isoform 5. MW: 57kD. Purity >90% as determined by SDS-PAGE. Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the for |
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| Size | 0.01 mg (E-Coli), 0.05 mg (E-Coli), 0.1 mg (E-Coli), 0.2 mg (E-Coli), 0.5 mg (E-Coli) |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [Triplet-expansion RNA-binding protein] |
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| Gene, Accession, CAS # | MBNL1, Gene ID: 4154, Accession: NP_001300986.1 |
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| Catalog # | MBS1292217 |
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| Order / More Info | Recombinant Human Muscleblind-like protein 1 from MYBIOSOURCE INC. |
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| Product Specific References | Borsani G., Barbieri A.Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.DNA Res. 4:307-313(1997) Recruitment of human muscleblind proteins to (CUG)(n) expansions associated with myotonic dystrophy.Miller J.W., Urbinati C.R., Teng-Umnuay P., Stenberg M.G., Byrne B.J., Thornton C.A., Swanson M.S.EMBO |
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