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| Product Name | Interleukin-36 gamma, active (Il36g), Recombinant, Mouse |
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| Description | Purity ≥98% as determined by SDS-PAGE and HPLC. Function as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2/IL1RL2. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP (By similarity). Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. May play a role in proinflammatory responses during particular neutrophilic airway inflammation. May be involved in the innate immune response to fungal pathogens. Induces the production of proinflammatory cytokines in bone marrow-derived dendritic cells (BMDCs), including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23. Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 |
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| Size | 2ug, 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Interleukin-1 family member 9 |
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| Gene, Accession, CAS # | IL36G_MOUSE, SwissProt: Q8R460 |
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| Catalog # | 348138 |
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| Order / More Info | Interleukin-36 gamma, active (Il36g), Recombinant, Mouse from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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