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| Product Name | B-Cell Linker (BLNK) (AA 1-456) protein (His tag) |
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| Description | B-Cell Linker Protein (BLNK) is a cell membrane protein which contains 1 SH2 domain. BLNK is expressed in B cells and fibroblast cell lines, playing a important role in B cell receptor signaling. BLNK as a central linker protein, downstream of the B-cell receptor (BCR), bridges the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. BLNK associates with the activation of ERK/EPHB2, MAP kinase p38 and JNK, modulates AP1, NF-kappa-B and NFAT activation. BLNK involves in BCR-mediated PLCG1 and PLCG2 activation and Ca2+ mobilization and is required for trafficking of the BCR to late endosomes. BLNK deficiency results in agammaglobulinemia type 4 and much more profound block in B-cell development.Alternative Names: B-Cell Linker Protein, B-Cell Adapter Containing a SH2 Domain Protein, B-Cell Adapter Containing a Src Homology 2 Domain Protein, Cytoplasmic Adapter Protein, Src Homology 2 Domain-Containing Leukocyte Protein of 65 kDa, SLP-65, BLNK, BASH, SLP65 |
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| Size | 10 µg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | BLNK|blnk|MGC147045|BASH|Bca|Ly-57|Ly57|Lyw-57|SLP-65|AGM4|BLNK-S|LY57|SLP65|bca |
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| Gene, Accession, CAS # | Gene ID: 29760 |
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| Catalog # | ABIN1096136 |
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| Order / More Info | B-Cell Linker (BLNK) (AA 1-456) protein (His tag) from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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