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| Antigenic Specificity | Dihydropyrimidine Dehydrogenase (DPYD) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | mouse, rat, human |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 50 µg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB),Immunohistochemistry (IHC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Dihydropyrimidine dehydrogenase (DPD, DPYD) catalyzes the initial and rate-limiting step in uracil and thymidine catabolism as well as catabolism of the chemotherapeutic drug 5-fluorouracil (5-FU) and its derivatives. DPYD deficiency, which results from mutations in the DPYD gene, causes errors in pyrimidine metabolism and potentially life-threatening side effects in cancer patients treated with 5-FU (reviewed in 1). As a result, ongoing work examines whether or how DPYD gene variation and protein expression can be used to predict 5-FU toxicity . Several genes that impart resistance to 5-FU were recently identified in human hepatocellular carcinoma (HCC). AEG-1, which is highly expressed in HCC, increases the expression of DPYD. DPYD is expressed more highly in HCC than in normal liver, and this is thought to be one mechanism of 5-FU resistance . Synonyms: DHP, DPD, DHPDHASE, |
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| Immunogen | Recombinant protein of human DPYD |
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| Other Names | DPYD|dpyd|zgc:77205|dhp|dhpdhase|dpd|14.t00017|DDBDRAFT_0189681|DDBDRAFT_0231100|DDB_0189681|DDB_0231100|DHP|DHPDHASE|DPD|AI315208|E330028L06Rik |
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| Gene, Accession # | Gene ID: 1806,99586,81656 |
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| Catalog # | ABIN1683543 |
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| Price | |
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| Order / More Info | Dihydropyrimidine Dehydrogenase (DPYD) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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