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| Product Name | Interleukin 1 Receptor Antagonist (IL1RN) (Active) protein |
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| Description | Interleukin-1 receptor antagonist (IL-1ra) is a member of the IL-1 family. Endogenous IL-1ra is produced in numerous animal disease models as well as in human autoimmune and chronic inflammatory diseases. It binds to IL-1 receptors in competition with IL-1, but does not elicit intracellular response from this binding. Its role in counteracting the proinflammatory effects of IL-1 is being studied by numerous research groups. IL-4 and IL-13 have been shown to amplify the stimulatory effect of IL1-beta on the production of soluble and intracellular forms of IL1-ra.The regulated expression of IL1ra in various cell types has been shown to be influenced by cytokines. In synovial fibroblasts the synthesis of IL-1ra is markedly enhanced by IL-1 , TNF-alpha , or PDGF. Synonym: Interleukin-1 receptor antagonist (IL-1ra), Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4. |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | IL1RN|DIRA|ICIL-1RA|IL-1RN|IL-1ra|IL-1ra3|IL1F3|IL1RA|IRAP|MVCD4|IRAP1|F630041P17Rik|icIL-1ra|IL-1RA |
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| Gene, Accession, CAS # | Gene ID: 3557 |
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| Catalog # | ABIN988018 |
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| Order / More Info | Interleukin 1 Receptor Antagonist (IL1RN) (Active) protein from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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