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| Product Name | Fms-Related Tyrosine Kinase 4 (FLT4) (Soluble) protein (His tag) |
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| Description | All three VEGF receptors belong to the class III subfamily of receptor tyrosine kinases (RTKs) characterised by the seven immunoglobulin-like loops in the extracellular domain. The expression of VEGFR-1 to -3 is almost exclusively restricted to hematopoietic precursor cells, vascular and lymphatic endothelial cells and to the monocyte/macrophage lineage. They play key roles in vasculogenesis, hematopoiesis, angiogenesis and lymphangiogenesis. The FLT-4 cDNA encodes a 1298 AA (aa) residue precursor protein with a 23 aa residue signal peptide. Mature VEGFR-3/FLT-4 is composed of a 751 aa residue extracellular domain, a 22 aa transmembrane domain and a 482 aa residue cytoplasmic domain. Both VEGF family members VEGF-C and VEGF-D have been shown to bind and activate VEGFR-3/FLT-4. The Flt-4 gene is widely expressed in the early embryo but becomes restricted to the lymphatic endothelial a latter stages of development. It is important for lymphangiogenesis Synonyms: Tyrosine-protein kinase receptor FLT4, PCL, FLT41, FMS-LIKE TYROSINE KINASE 4, VEGFR-3, VEGFR3. |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | AI323512|Chy|Flt-4|VEGFR-3|VEGFR3|FLT41|LMPH1A|PCL|Vegfr3|cb1059|6130401C07|Flk-1|Flk1|Krd-1|Ly73|VEGFR-2|VEGFR2|sVEGFR-2 |
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| Gene, Accession, CAS # | Gene ID: 2324 |
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| Catalog # | ABIN806361 |
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| Order / More Info | Fms-Related Tyrosine Kinase 4 (FLT4) (Soluble) protein (His tag) from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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