| 产品详情 |
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| Antigenic Specificity | B-Cell CLL/lymphoma 10 (BCL10) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | mouse, rat, human |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB),Immunohistochemistry (IHC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Bcl10/CIPER/CLAP/mE10 is a widely expressed CARD (caspase recruitment domain) containing protein shown to induce apoptosis and activate NF-kappaB. The CARD domain mediates self-oligomerization, interactions with other CARD proteins and is necessary for NF-kappaB activation, although the precise mechanism which Bcl10 regulates these processes is not fully understood. The discovery of Bcl10 came from observations of the chromosomal translocation t(p22, q32) from B cell lymphomas of the mucosa-associated lymphoid tissue (MALT). This translocation results in deregulated expression of a truncated form of Bcl10 which lacks apoptotic activity and enhances transformation. Studies from Bcl10 deficient mice demonstrate that Bcl10 is essential for the activation of NF-kappaB by T- and B-cell receptors. One third of Bcl10 deficient mice developed lethal exencephaly. Surviving mice were unaffected by various apoptotic stimuli, but were severely immunodeficient and defective in antigen receptor-induced NF-kappaB activiation. PKC or T-cell receptor signaling results in a downregulation of Bcl10 protein levels, attenuating both NF-kappaB activation and cellular proliferation and also provides a negative feedback regulation of the NF-kappaB signaling to T cell signaling.Synonyms: BCL10, CARMEN, CIPER, CLAP, c-E10, mE10 |
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| Immunogen | Recombinant protein of human BCL10 |
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| Other Names | BCL10|AI132454|BCL-10|C81403|CARMEN|CIPER|CLAP|ME10|cE10|c-E10|mE10 |
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| Gene, Accession # | Gene ID: 8915,12042,83477 |
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| Catalog # | ABIN1512624 |
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| Price | |
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| Order / More Info | B-Cell CLL/lymphoma 10 (BCL10) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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