| 产品详情 |
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| Product Name | LFM-A13 |
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| Description | Purity >97%. Bruton's tyrosine kinase (BTK) is a member of the BTK/Tec family of protein tyrosine kinases involved in signal transduction pathways regulating growth and differentiation of B cells. BTK acts as an inhibitor of Fas/APO-1-mediated apoptosis in B cells by preventing FAS-FADD interaction. LFM-A13 is an anti-leukemia agent with apoptosis-promoting and chemosensitizing properties. It acts as an inhibitor of Bruton's tyrosine kinase (BTK) and Polo-like kinase (Plk) with IC50 values of 2.5 µM (mouse recombinant) and 10 µM (Xenopus), respectively. LFM-A13 exhibits minor inhibitory activity against a number of other protein kinases including JAK1, JAK2, EGFR, IRK, IKK, and Cdk1, 2 and 3, as well as several other related kinases. LFM-A13 also exhibits anti-proliferative activity against HER2/Neu-overexpressing breast cancer cells. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2Z-cyano-N-(2,5-dibromophenyl)3-hydroxy-2-butenamide |
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| Gene, Accession, CAS # | CAS: 244240-24-2 |
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| Catalog # | LS-H38 |
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| Order / More Info | LFM-A13 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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