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| Product Name | Interferon Regulatory Factor 3 (IRF3) (AA 1-112) protein |
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| Description | Members of the Interferon regulatory factor (IRF) family regulate gene expression critical to immune response, hemopoiesis, and proliferation. IRF-3 is a member of the IRF family, and is distinct from other family members. Its transcriptional activity is regulated solely by posttranslational modifications. It plays a crucial role in activation of innate immunity and inflammation in response to viral infection. IRF-3 mediates interferon-stimulated response element (isre) promoter activation. Functions as a molecular switch for antiviral activity. Dsrna generated during the course of an viral infection leads to IRF3 phosphorylation on the c-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with creb binding protein (crebbp) to form dsrna-activated factor 1 (draf1), a complex which activates the transcription of genes under the control of isre. The complex binds to the ie and prdiii regions on the ifn-alpha and ifn-beta promoters respectively. IRF-3 does not have any transcription activation domains Synonyms: IRF-3, IRF3, Interferon Regulatory Factor 3 |
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| Size | 20 µg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | irf3|IRF3|C920001K05Rik|IRF-3 |
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| Gene, Accession, CAS # | Gene ID: 3661 |
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| Catalog # | ABIN804082 |
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| Order / More Info | Interferon Regulatory Factor 3 (IRF3) (AA 1-112) protein from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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