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| Product Name | FceRI, alpha, Recombinant, Human, 6-His-Tag |
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| Description | Purity ~95% (SDS-PAGE). The A subunit of the high affinity IgE receptor (Fce RIA or FceRIA) is an IgE-binding type I transmembrane glycoprotein of the multichain immune recognition (MIRR) family. The receptor, Fce RI, is a tetrameric complex of oneA, one B and two G subunits (ABG2) on mast cells and basophils. An alternate trimeric form (AB2) is expressed on human, but not rodent, mast cells, basophils, eosinophils and professional antigen presenting cells. While the G subunit is essential for expression of Fce RIA on the cell surface and for cell signaling, the B subunit, when present, increases the halflife of the Fce RI complex on the cell surface. An isoform of the B subunit, BT, blocks processing of the A subunit and its cell surface expression. Human Fce RIA cDNA encodes 257aa including a 25aa signal sequence, a 180aa extracellular domain containing two Ig-like domains that bind IgE and an endoplasmic reticulum retention motif, a 21aa transmembrane domain with a charged aa (Asp21 |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | FceRI, alpha, Recombinant, Human, 6-His-Tag (Fc epsilon RI alpha, FCE1A, FCER1A, High Affinity Immunoglobulin epsilon Receptor Subunit alpha, IgE Receptor) |
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| Gene, Accession, CAS # | Accession: NP_001992 |
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| Catalog # | F0025-07 |
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| Order / More Info | FceRI, alpha, Recombinant, Human, 6-His-Tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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