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| Antigenic Specificity | Calcium Channel, Voltage-Dependent, L Type, alpha 1S Subunit (CACNA1S) (N-Term) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, rat, mouse |
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| Isotype | n/a |
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| Format | serum |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (IHC),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle.Subcellular location: Membrane, Multi-pass membrane protein.Tissue specificity: Skeletal muscle specific. Defects in CACNA1S are a cause of periodic paralysis hypokalemic (HOKPP), also designated HYPOPP. HOKPP is an autosomal dominant disorder manifested by episodic flaccid generalized muscle weakness associated with falls of serum potassium levels. Defects in CACNA1S are the cause of malignant hyperthermia susceptibility 5 (MHS5), an autosomal dominant disorder that is potentially lethal in susceptible individuals on exposure to commonly used inhalational anesthetics and depolarizing muscle relaxants. Also known as: Voltage-dependent L-type calcium channel subunit alpha-1S, Voltage-gated calcium channel subunit alpha Cav1.1, Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle, CACH1, CACN1, CACNL1A3, CAC1S, Cav1.1. |
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| Immunogen | A synthetic peptide from n-terminal of human CACNA1S (Cav1.1) conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat and mouse. |
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| Other Names | CACNA1S|cav1.1|ca(v)1.1|CACNL1A3|CCHL1A3|Cav1.1|HOKPP|HOKPP1|MHS5|TTPP1|hypoPP|AW493108|Cchl1a3|fmd|mdg|sj|caV1.1 |
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| Gene, Accession # | Gene ID: 779,12292,682930 |
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| Catalog # | ABIN350148 |
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| Order / More Info | Calcium Channel, Voltage-Dependent, L Type, alpha 1S Subunit (CACNA1S) (N-Term) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 16710414, 7713519, 17418573, 19118277, 7987325 |
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