| 产品详情 |
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| Antigenic Specificity | RuvA |
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| Clone | 12C6 |
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| Host Species | Mouse |
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| Reactive Species | E. coli |
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| Isotype | IgG1 |
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| Format | Protein G purified |
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| Size | 0.1 mg |
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| Concentration | n/a |
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| Applications | Enzyme Immunoassay (EIA),Immunoprecipitation (IP),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | In Escherichia coli, the RuvA, RuvB and RuvC proteins are required for the late stages of homologous recombination and DNA repair. They are involved in processing the Holliday junction.during homologous recombination. RuvA protein binds to both single-stranded and doublestranded DNA. RuvB protein has weak ATPase activity. RuvA bound to DNA greatly enhances ATPase activity of RuvB. UV- rradiation to supercoiled DNA further enhances the stimulatory effect of RuvA on the RuvB ATPase activity. In the presence of ATP the RuvA-RuvB complex has an activity that renatures cruciform structures formed by heating and gradually cooling supercoiled DNA with an inverted repeat. RuvA and RuvB promote branch migration whereas RuvC resolves junctions by endonucleolytic cleavage. Moreover RuvAB stimulate Holliday junction resolution by RuvC. The RuvA-RuvB complex interacts with an irregular conformation in damaged DNA and induces conformational changes in DNA using energy provided by ATP hydrolysis, so that it facilitates DNA repair, recombination and error prone replication. RuvABC proteins are responsible for the occurrence of DSBs at arrested replication forks. In cells proficient for RecBC, RuvAB is uncoupled from RuvC and DSBs may be prevented. |
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| Immunogen | RuvA protein from E. coli. Remarks: Mol. Wt. of Antigen: 22 kDa |
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| Other Names | Holliday junction ATP-dependent DNA helicase ruvA |
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| Gene, Accession # | n/a |
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| Catalog # | ABIN180382 |
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| Price | |
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| Order / More Info | RuvA Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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