| 产品详情 |
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| Antigenic Specificity | ROBO1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | biotin conjugate |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | ELISA |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | ROBO1 Antibody (Biotin) LS-C502197. Specificity: Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10102268, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). May be required for lung development (By similarity). |
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| Immunogen | Recombinant Human Roundabout homolog 1 protein (29-143AA) |
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| Other Names | ROBO1, Deleted in U twenty twenty, H-Robo-1, Roundabout 1, SAX3, DUTT1, Roundabout homolog 1 |
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| Gene, Accession # | ROBO1, Gene ID: 6091 |
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| Catalog # | LS-C502197 |
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| Price | |
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| Order / More Info | ROBO1 Antibody from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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