| 产品详情 |
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| Antigenic Specificity | PION |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 20 µg/mL, Immunofluorescence: 20 µg/mL, Immunohistochemistry: 5 µg/mL, Western Blot: 0.25 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | PION Polyclonal Antibody. Accumulation of the amyloid-beta peptide (Abeta) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. The beta-amyloid protein precursor (APP) is cleaved by one of two beta-secretases (BACE and BACE2), producing a soluble derivative of the protein and a membrane anchored 99 -amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for -gamma-secretase to generate the 4 kDa amyloid-beta peptide (Abeta), which is deposited in the Alzheimer's disease patients' brains. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both -gamma-secretase and the APP C-terminal fragment, suggesting that PION may be a |
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| Immunogen | n/a |
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| Other Names | tcag7.1314, GSAP; gamma-secretase-activating protein; protein pigeon homolog |
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| Gene, Accession # | Entrez: 212167, 311984, 54103; Uniprot: A4D1B5, Q3TCV3 |
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| Catalog # | PA5-21092 |
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| Price | |
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| Order / More Info | PION Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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