| 产品详情 |
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| Antigenic Specificity | IL4 |
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| Clone | 11B4 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgM |
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| Format | purified |
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| Size | 100µg/50µg |
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| Concentration | n/a |
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| Applications | ELISA, IP, Neutralization of IL4 bioactivity |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Interleukin-4 (IL-4) is a monomeric 20 kDa predominantly produced by activated T lymphocytes of the Th2 phenotype, by mast cells and by some antigen-presenting cells. Together with IL-2, IL-4 is an autocrine growth factor for activated T cells and for cytotoxic T cell precursors. IL-4 is a major factor involved in the activation of resting B lymphocytes. Together with IL-13, IL-4 induces isotype switch towards IgE and IgG1 isotypes. 11B4, was produced from a rat immunized with purified human IL4-transfected-COS7 cells. It recognized both E. coli-expressed and mammalian cell-expressed (COS7 and L cell), rhuIL-4 in solution (immunoprecipitation), as well as on solid phase (indirect ELISA and dot-blotting). The 11B4 antibody inhibited IL-4 bioactivity at an IC50 which was 25-50-fold in molar excess of factor. The 11B4 antibody was used to develop an immunoenzymatic assay capable of detecting concentrations less than 100 pg/ml. (Chretien I et al, 1989, J. Immunol. Methods, 1178 (1) : 67-81; Ramanathan L.et al, 1993, Biochemistry, 32 (14) :3549-56). |
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| Immunogen | n/a |
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| Other Names | interleukin |
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| Gene, Accession # | n/a |
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| Catalog # | DDX0311 |
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| Price | |
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| Order / More Info | IL4 Antibody from DENDRITICS SAS |
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| Product Specific References | n/a |
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