| Edit |   |
|---|
| Antigenic Specificity | Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (N-Term), (aa 4-31) |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | human |
|---|
| Isotype | n/a |
|---|
| Format | unconjugated |
|---|
| Size | 50 µg |
|---|
| Concentration | n/a |
|---|
| Applications | Immunoprecipitation (IP),Western Blotting (WB) |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | TRIF is involved in innate immunity against invading pathogens. It is an adaptor used by TLR3 and TLR4 (through TICAM-2) to mediate NF-kappaB and interferon-regulatory factor (IRF) activation and to induce apoptosis. Ligand binding to TLR3 and TLR4 results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappaB and FADD respectively. TRIF is ubiquitously expressed with higher levels in liver. |
|---|
| Immunogen | Synthetic peptide corresponding to aa 4-31 (T4GPSLPSAFDILGAAGQDKLLYLKHKLK31) of N-terminal human TRIF. |
|---|
| Other Names | IIAE6|MyD88-3|PRVTIRB|TICAM-1|TRIF|AW046014|AW547018|trif |
|---|
| Gene, Accession # | Gene ID: 148022 |
|---|
| Catalog # | ABIN1169062 |
|---|
| Price | |
|---|
| Order / More Info | Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (N-Term), (aa 4-31) Antibody from ANTIBODIES-ONLINE GmbH |
|---|
| Product Specific References | PubMed: 16964262, 17138826, 18756281 |
|---|