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| Product Name | Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) (AA 1-700) protein (His tag) |
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| Description | IKK-beta is a serine kinase that plays an essential role in the NF-kappaB signaling pathway, which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. It acts as part of the canonical IKK complex in the conventional pathway of NF-kappaB activation. It phosphorylates inhibitors of NF-kappaB and these modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. Subsequently, NF-kappaB is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. IKK-beta phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappaB subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. It phosphorylates also other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, it acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappaB activation. |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | SDS-PAGE (SDS) |
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| Other Names | ikk-beta|ikk2|ikkb|ikkbeta|IKBKB|IKKB|CG4201|DIK|DLAK|DmIKK|DmIKKBeta|DmIKKb|DmIKKbeta|DmIkkbeta|Dmel\\CG4201|Dmikkb|Dmikkbeta|IK|IKK|IKK-beta|IKKb|IKKbeta|IRD-5|IRD5|Ik|Ikkb|Ikkbeta|Ird-5|Ird5|LRK|Lak|anon-89Bd|dIKK|dIKK-beta|dIKKbeta|dLak|dmIKKbeta|ikk|ird|ird5/DmIkk[beta]|IKK2|NFKBIKB|AIM-1|AI132552|IKK-2|IKK[b] |
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| Gene, Accession, CAS # | Gene ID: 3551 |
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| Catalog # | ABIN2745713 |
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| Order / More Info | Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) (AA 1-700) protein (His tag) from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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