| 产品详情 |
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| Antigenic Specificity | SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3) (aa 840-857) |
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| Clone | S69-46 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | Atto 700 conjugate |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Immunocytochemistry (ICC),Immunofluorescence (IF),Immunohistochemistry (IHC),Immunoprecipitation (IP),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins. Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Shank proteins are also crucial in receptor tyrosine kinase signaling, specifically, Shank3 can mediate Erk-MAPK and P13K signaling which is crucial for tubule formation. Shank3 is also one of the latest genes to be associated with autism. A mutation of a single copy of Shank3 on chromosome 22q13 can result in language and/or social communication disorders.Cellular Localization: Cytoplasm, Cell Junction | synapse | postsynaptic cell membrane | postsynaptic density |
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| Immunogen | Synthetic peptide amino acids 840-857 of rat Shank3 |
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| Other Names | DEL22q13.3|PROSAP2|PSAP2|SCZD15|SPANK-2|Prosap2|AI841104|Shank3b |
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| Gene, Accession # | Gene ID: 85358,58234,59312 |
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| Catalog # | ABIN2485409 |
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| Price | |
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| Order / More Info | SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3) (aa 840-857) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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