| 产品详情 |
| Edit |   |
|---|
| Product Name | Aurora Kinase A (AURKA) (AA 1-403) protein (His tag) |
|---|
| Description | AURKA (Aurora Kinase A) belongs to the mitotic serine/threonine kinases family. AURKA is a cell cycle-regulated kinase which may be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. AURKA is found at the centrosome in interphase cells and at the spindle poles in mitosis. Since the AURKA expression is cell-cycle regulated, it is low in G1/S, it accumulates during G2/M, and it decreases rapidly after. AURKA is involved in important processes during mitosis and meiosis whose proper function is essential for healthy cell proliferation. In addition, AURKA plays an essential role in tumourigenesis and is overexpressed in various types of cancers. AURKA is strongly expressed in the testis, colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines and weakly in skeletal muscle, thymus and spleen. AURKA interacts with its substrates BORA and ARHGEF2, as well as with TACC1 and CPEB1.Defects in the AURKA gene cause numerical centrosome aberrations including aneuploidy. AURKA overexpression has been linked to chromosomal instability in colorectal cancer. AURKA expression may have a prognostic significance in ovarian carcinoma Synonyms: Serine/threonine-protein kinase 6, Aurora kinase A, Serine/threonine kinase 15, Aurora/IPL1-related kinase 1, Breast tumor-amplified kinase, Aurora-A, Aurora-related kinase 1, hARK1, AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6, STK7, STK15, AURORA2, MGC34538 |
|---|
| Size | 10 µg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | 87A7-9/2|Aur-A|AurA|CG3068|Dmel\\CG3068|aur-A|aurA|ck10|ck[10]|l(3)87Ac|l(3)ck10|Aurora-A|Eg2|aik|ark1|aur-a|aura|aurora2|btak|pEg2|stk15|stk6|stk7|wu:fb37c10|wu:fc02c02|zgc:100912|AURKA|aurka|AIK|ARK1|AURA|AURORA2|BTAK|PPP1R47|STK15|STK6|STK7|AIRK1|AU019385|AW539821|Ark1|Ayk1|IAK|IAK1|Stk6|ARK-1|aurka-a |
|---|
| Gene, Accession, CAS # | Gene ID: 6790 |
|---|
| Catalog # | ABIN806503 |
|---|
| Price | |
|---|
| Order / More Info | Aurora Kinase A (AURKA) (AA 1-403) protein (His tag) from ANTIBODIES-ONLINE GmbH |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|