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| Product Name | L-902,688 |
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| Description | Purity >98%. Prostaglandin E2 (PGE2 ) activates four E prostanoid (EP) receptors, EP1-4 . EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. L-902,688 is a highly potent agonist of the human PGE2 receptor, EP4 . It demonstrates a Ki value of 0.38 nM and an EC50 value of 0.6 nM and is >4,000-fold selective for EP4 over other EP and prostanoid receptors. L-902,688 induces thermal hyperalgesia when injected into guinea pig forepaw and increases vasodilation of human pulmonary vein. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5-[(1E,3R)-4,4-difluoro-3-hydroxy-4-phenyl-1-buten-1-yl]-1-[6-(2H-tetrazol-5R-yl)hexyl]-2-pyrrolidinone |
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| Gene, Accession, CAS # | CAS: 634193-54-7 |
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| Catalog # | LS-H8394 |
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| Price | |
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| Order / More Info | L-902,688 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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