| 产品详情 |
| Edit |   |
|---|
| Product Name | L-655,240 |
|---|
| Description | Purity >98%. The lipid mediator thromboxane (TX)A2 plays a key role in platelet aggregation and vascular and bronchial smooth muscle constriction. The actions of TXA2 are mediated by its specific G protein-coupled receptor, referred to as the TXA2 receptor or TP. Two isoforms, TPAlpha and TPBeta, are produced from a single gene, differ in their carboxyl termini, and form homo- and hetero-oligomers. While both isoforms signal through similar pathways, they differ in the modulation by certain agonists. L-655,240 is a potent antagonist of the TP receptor in vitro (IC50 = 7 nM). It also is effective at blocking TP-mediated bronchoconstriction in vivo and platelet aggregation ex vivo . Whether the two TP isoforms differ in their sensitivity to L-655,240 is not known. |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | 1-[(4-chlorophenyl)methyl]-5-fluoro-a,a,3-trimethyl-1H-indole-2-propanoic acid |
|---|
| Gene, Accession, CAS # | CAS: 103253-15-2 |
|---|
| Catalog # | LS-H8390 |
|---|
| Price | |
|---|
| Order / More Info | L-655,240 from LIFESPAN BIOSCIENCES INC. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|