| 产品详情 |
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| Product Name | L524-0366 |
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| Description | Purity >98% by NMR, TLC. L524-0366 is an Fn14 antagonist. Competes with TNF-like weak inducer of apoptosis (TWEAK) C-terminal/extracellular TNF homology domain (THD) for Fn14 binding (KD = 7.12 uM). It specifically inhibits TWEAK-Fn14-mediated NFkB activation. L524-0366 completely suppressed TWEAK-induced T98G cell migration (10 uM) without cytotoxicity up to 50 uM. L524-0366 is the first compound known to interfere with the TWEAK/Fn14 inter-action and may serve as a lead compound for the development of new therapeutics. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (1-(3-Chlorophenyl)-1H-1,2,3-triazol-4-yl)(thiomorpholino)methanone |
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| Gene, Accession, CAS # | CAS: 951612-19-4 |
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| Catalog # | LS-H14735 |
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| Order / More Info | L524-0366 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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