| 产品详情 |
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| Product Name | L002 |
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| Description | Purity >98%. L002 is an inhibitor of p300 histone acetyltransferase (KAT3B; IC50 = 1.98 µM in vitro ). It has weaker inhibitory effects against PCAF and GCN5 (IC50 s = 35 and 34 µM, respectively) and is specific for p300 over a panel of additional acetyltransferases, deacetylases, and methyltransferases. L002 blocks acetylation of histones and p53 in cells treated with trichostatin A or etoposide, respectively, and reduces STAT3 phosphorylation, which requires p300-mediated acetylation of STAT3. It induces growth arrest and apoptosis in certain cancer cell lines and, when administered intraperitoneally in mice, suppresses the growth of triple-negative breast cancer xenografts. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2,6-dimethyl-2,5-cyclohexadiene-1,4-dione 4-[O-[(4-methoxyphenyl)sulfonyl]oxime], NSC 764414, p300/CBP Inhibitor VI |
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| Gene, Accession, CAS # | CAS: 321695-57-2 |
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| Catalog # | LS-H8387 |
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| Price | |
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| Order / More Info | L002 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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