| 产品详情 |
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| Antigenic Specificity | CD8 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | mouse |
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| Isotype | n/a |
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| Format | Protein A purified |
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| Size | 100 ug, 200 ug |
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| Concentration | n/a |
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| Applications | ICC, IF, IHC-P, P-ELISA, WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Rabbit polyclonal to CD8, was first discovered as a cell surface marker in mice and was used to distinguish between CD8+ CTLs and CD4+ Th cells. CD8 exists as both a heterodimer (CD8??) and a homodimer (CD8??) of which the former is expressed on the majority of CTLs. CD8 has been shown to be involved in CTL co-activation by increasing antigen sensitivity, and by stabilizing the TCR/pMHC interaction. In order to carry out these roles, the CD8 co-receptor binds to a distinct invariant region of the pMHCI molecule, compared to the TCR, allowing the potential for tripartite (TCR/pMHC/CD8) complex formation. CD8 is most often described as a T-cell co-receptor because it plays an important role in T-cell signaling, via p56lck, to induce TCR mediated T-cell activation signals. Work in our lab and others has shown that the CD8 co-receptor is also important for CD8+ T-cell development, stabilization of the interface between CD8+ T-cells and target cells, and activation of intestinal epithelial T lymphocytes (iIELs). |
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| Immunogen | KLH conjugated synthetic peptide derived between 61-140 amino acids of human CD8 |
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| Other Names | CD 8a, CD8 alpha chain, CD8, CD8 antigen alpha chain, CD8 antigen alpha polypeptide, CD8 antigen alpha polypeptide (p32), CD8a, CD8a antigen, CD8a molecule, CD8A_MOUSE, Leu 2, Leu2, Leu2 T lymphocyte antigen, MAL, OKT8 T cell antigen, OTTHUMP00000160760, OTTHUMP00000160764, OTTHUMP00000203528, OTTHUMP00000203721, p32, T cell antigen Leu2, T cell co receptor, T cell coreceptor, T cell surface glycoprotein CD8 alpha chain, T lymphocyte differentiation antigen T8/Leu 2, T lymphocyte differentiation antigen T8/Leu2, T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2, T8 T cell antigen, Cd8a, Lyt-2, Lyt2 |
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| Gene, Accession # | Gene ID: 925, UniProt: P01732 (Human); P10966 (Human); P01731 (Mouse); P10300 (Mouse) |
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| Catalog # | orb312181 |
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| Price | |
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| Order / More Info | CD8 Antibody from BIORBYT LTD. |
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| Product Specific References | n/a |
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| 产品资料 |
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