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| Product Name | Interferon tau-2 (Active) protein |
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| Description | IFN-tau is a new class of type I IFN that is secreted by the trophoblast and is the signal for maternal recognition of pregnancy in sheep. IFN- tau has potent immunosuppressive and antiviral activities similar to other type I IFN but is less cytotoxic than IFN-α/beta. The current investigation concerns the effect of recombinant ovine IFN- tau (rOvIFN- tau) on the modulation of MHC class I and II expression on cloned mouse cerebrovascular endothelial (CVE) cells. IFN- tau induced tyrosine phosphorylation of Stat1 and upregulated the expression of MHC class I on CVE. One proposed action by which type I IFN reduce the relapse rate in MS is via interference with IFN-γ-induced MHC class II expression. IFN- tau was shown to downregulate IFN-γ-induced MHC class II expression on CVE and, hence, may be of potential therapeutic value in downregulating inflammation in the central nervous system (CNS). IFN- tau did not upregulate the expression of MHC class II on CVE. IFN- tau also inhibited the replication of Theiler's virus in CVE. Synonym: Interferon-tau ( IFN-tau ), Ovine. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4. |
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| Size | 10 µg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | IFN-tau-c2|IFNT|IFNT1|TP-1|TP-1P8|IFNT2|IFN-tau2 |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | ABIN988005 |
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| Order / More Info | Interferon tau-2 (Active) protein from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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