| 产品详情 |
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| Product Name | Abiraterone Acetate |
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| Description | Purity >98%. The cytochrome P450 (CYP) isoform CYP17A1 is also known as steroid 17Alpha-hydroxylase/17,20 lyase because it catalyzes both 17Alpha-hydroxylase and 17,20 lyase reactions in the synthesis of steroids, including androgens, estrogens, glucocorticoids, and mineralocorticoids. Abiraterone acetate blocks CYP17A1 by potently inhibiting both the 17Alpha-hydroxylase and the 17,20 lyase activities (IC50 = 18 and 17 nM, respectively). In mice as well as men, it essentially eliminates plasma testosterone while producing a 3- to 4-fold increase in plasma luteinizing hormone. It improves radiographic progression-free survival and significantly delays decline in human metastatic castration-resistant prostate cancer. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (3Beta)-17-(3-pyridinyl)-androsta-5,16-dien-3-ol, acetate ester, CB-7630, Zytiga® |
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| Gene, Accession, CAS # | CAS: 154229-18-2 |
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| Catalog # | LS-H6377 |
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| Price | |
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| Order / More Info | Abiraterone Acetate from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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