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| Product Name | Interleukin-1 (IL-1) Receptor Antagonist (Active) protein |
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| Description | Interleukin-1 receptor antagonist (IL-1ra) is a member of the IL-1 family. Endogenous IL-1ra is produced in numerous animal disease models as well as in human autoimmune and chronic inflammatory diseases. It binds to IL-1 receptors in competition with IL-1, but does not elicit intracellular response from this binding. Its role in counteracting the proinflammatory effects of IL-1 is being studied by numerous research groups. IL-4 and IL-13 have been shown to amplify the stimulatory effect of IL1-beta on the production of soluble and intracellular forms of IL1-ra. The regulated expression of IL1ra in various cell types has been shown to be influenced by cytokines. In synovial fibroblasts the synthesis of IL-1ra is markedly enhanced by IL-1 , TNF-alpha , or PDGF. Recombinant Human IL-1RN produced in E. coli is a non-glycosylated, N-terminal methionyl form of the human naturally-occurring polypeptide chain containing 153 amino acids and having a molecular mass of 17,258 Da. Synonym: rHuIL-1ra, IL1 Receptor Antagonist, Interleukin-1 Receptor Antagonist, Interleukin1 Receptor Antagonis. Formulation: The protein was lyophilized after extensive dialysis against 50mM Tris-HCl, pH7.5, 200mM NaCl buffer. |
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| Size | 50 µg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | ABIN988011 |
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| Order / More Info | Interleukin-1 (IL-1) Receptor Antagonist (Active) protein from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 16855172, 16777324, 21659536 |
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