| 产品详情 |
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| Antigenic Specificity | Contactin 1 (CNTN1) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, rat |
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| Isotype | n/a |
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| Format | serum |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (IHC),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Function:Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth.Subunit: Monomer. Interacts with CNTNAP1 in cis form. Binds to the carbonic-anhydrase like domain of protein-tyrosine phosphatase zeta. Interacts with NOTCH1 and TNR.Subcellular location: Cell membrane, Lipid-anchor, GPI-anchor.Miscellaneous: F3 shares with L1, N-CAM, MAG, and other cell adhesion molecules from nervous tissue the L2/HNK-1 carbohydrate epitope.Tissue specificity: Strongly expressed in brain and in neuroblastoma and retinoblastoma cell lines. Lower levels of expression in lung, pancreas, kidney and skeletal muscle. Also known as: Neural cell surface protein F3, F3cam,Contactin 1, CNTN1, Glycoprotein gp135. |
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| Immunogen | A synthetic peptide from human contactin-1 (F3cam, contactin 1, CNTN1) conjugated to an immunogenic carrier protein was used as the antigen. |
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| Other Names | F3/F11|cntn-A|CNTN1|F3|GP135|AW495098|CNTN|F3cam|F11 |
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| Gene, Accession # | Gene ID: 1272,117258 |
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| Catalog # | ABIN350243 |
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| Price | |
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| Order / More Info | Contactin 1 (CNTN1) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 2026173, 7959734, 16335952, 14702039, 8164510, 16959974 |
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