| 产品详情 |
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| Product Name | AZ-6102 |
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| Description | AZ-6102 is a potent TNKS1/2 inhibitor (Tankyrase) that displays >100-fold selectivity against other poly (ADP-ribose) polymerase (PARP) family enzymes and inhibits Wnt pathway with IC50 value of 5 nM in DLD-1 cells. Inhibition of the PARP catalytic domain of the tankyrases is known to inhibit the Wnt pathway via increased stabilization of Axin. Wnt pathway plays important role in cancer, tissue homeostasis; germline mutations of various Wnt pathway components as Axin can lead to oncogenesis. MW: 428.54. Purity ≥98% by HPLC |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-(4-(6-((3R,5S)-3,5-dimethylpiperazin-1-yl)-4-methylpyridin-3-yl)phenyl)-7-methyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one |
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| Gene, Accession, CAS # | CAS: 1645286-75-4 |
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| Catalog # | B1200-5 |
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| Order / More Info | AZ-6102 from BIOVISION, INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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