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| Product Name | 11-deoxy-11-methylene Prostaglandin D2 |
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| Description | Prostaglandin D2 (PGD2) is one of the five primary enzymatic prostaglandins derived directly from PGH2. PGD2 is produced abundantly in the CSF by the lipocalin-type PGD synthase, and in the periphery by myeloid cells including mast cells and basophils by a second, leukocyte-type PGD synthase.{9588} PGD2 is chemically unstable, and its use and analysis is complicated by its short in vivo half-life. 11-deoxy-11-methylene PGD2 is a novel, chemically stable, isosteric analog of PGD2 wherein the 11-keto group is replaced by an exocyclic methylene. In the PGE series, the analogous modification leads to a stable, somewhat less potent agonist which embodies the same uterine stimulant and cervical ripening activities as the parent prostaglandin.{7894} However, 11-deoxy-11-methylene PGD2 has been reported by one group to be essentially without agonist activity on human platelets, a DP1 receptor assay.{11175} The CRTH2-receptor actions of 11-deoxy-11-methylene PGD2 are not yet reported. |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 11-deoxy-11-methylene PGD2 |
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| Gene, Accession, CAS # | CAS: 100648-29-1 |
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| Catalog # | 12410-10 |
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| Order / More Info | 11-deoxy-11-methylene Prostaglandin D2 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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